Umnyango Wezokwelapha Zaselabhorethri, Isibhedlela Sabantu sase-Guangxi Zhuang Autonomous Region, Nanning, China
Umnyango Wezokwelapha Zaselabhorethri, Isibhedlela Esihlanganisiwe saseShandong University of Traditional Chinese Medicine, iJinan
Huang Huayi, School of Laboratory Medicine, Youjiang National Medical University, Baise, Guangxi, 533000, Mindray North America, Mahwah, New Jersey, 07430, USA.
Umnyango Wezokwelapha Zaselabhorethri, Isibhedlela Sabantu sase-Guangxi Zhuang Autonomous Region, Nanning, China
Umnyango Wezokwelapha Zaselabhorethri, Isibhedlela Esihlanganisiwe saseShandong University of Traditional Chinese Medicine, iJinan
Huang Huayi, School of Laboratory Medicine, Youjiang National Medical University, Baise, Guangxi, 533000, Mindray North America, Mahwah, New Jersey, 07430, USA.
Sebenzisa isixhumanisi esingezansi ukuze wabelane ngenguqulo yombhalo egcwele yalesi sihloko nabangani bakho nozakwenu.Funda kabanzi.
Ukuze uqonde kangcono izinguquko ze-pathological ze-COVID-19, kuyasiza ekuphathweni komtholampilo kwalesi sifo kanye nokulungiselela igagasi lezifo eziwubhadane ezifanayo esikhathini esizayo.
Imingcele ye-hematological yeziguli ezingama-52 ze-COVID-19 engeniswe ezibhedlela eziqokiwe yahlaziywa kabusha.Idatha yahlaziywa kusetshenziswa isofthiwe yezibalo ye-SPSS.
Ngaphambi kokwelashwa, ama-T cell subsets, ama-lymphocyte aphelele, ububanzi bokusabalalisa kwamangqamuzana egazi abomvu (RDW), ama-eosinophils nama-basophil ayephansi kakhulu kunangemva kokwelashwa, kuyilapho izinkomba zokuvuvukala kwama-neutrophils, ama-neutrophils nama-lymphocytes Isilinganiso (NLR) kanye ne-C β-reactive protein ( Amazinga e-CRP) kanye namaseli abomvu egazi (RBC) kanye ne-hemoglobin yehle kakhulu ngemva kokwelashwa.Ama-T cell subsets, ama-lymphocyte aphelele kanye nama-basophil eziguli ezinzima nezigula kakhulu ayephansi kakhulu kunalawo eziguli ezilinganiselayo.I-Neutrophils, i-NLR, i-eosinophils, i-procalcitonin (i-PCT) ne-CRP iphakeme kakhulu ezigulini ezinzima nezigula kakhulu kuneziguli ezilinganiselwe.Ama-CD3+, CD8+, ama-lymphocyte esewonke, ama-platelet, nama-basophil eziguli ezineminyaka engaphezu kuka-50 ubudala aphansi kunalawo angaphansi kweminyaka engu-50 ubudala, kuyilapho ama-neutrophils, i-NLR, i-CRP, i-RDW ezigulini ezineminyaka engaphezu kwengu-50 ubudala ephakeme kunaleyo engaphansi kweminyaka engu-50 ubudala.Ezigulini ezigula kakhulu nezigula kakhulu, kukhona ukuhlobana okuhle phakathi kwesikhathi se-prothrombin (PT), i-alanine aminotransferase (ALT) ne-aspartate aminotransferase (AST).
Ama-T cell subsets, i-lymphocyte count, i-RDW, i-neutrophils, i-eosinophils, i-NLR, i-CRP, i-PT, i-ALT ne-AST ziyizinkomba ezibalulekile ekuphatheni, ikakhulukazi ezigulini ezigula kakhulu nezigula kakhulu ezine-COVID-19.
Umqedazwe we-2019 Coronavirus Disease (COVID-19) obangelwa uhlobo olusha lwe-coronavirus waqubuka ngoDisemba 2019 futhi wasakazeka ngokushesha emhlabeni wonke.I-1-3 Ekuqaleni kokuqubuka, ukugxila emtholampilo kwakugxile ekubonakalisweni kanye ne-epidemiology, kuhlanganiswe ne-computed tomography ukuze kufane neziguli ezingu-4 no-5, bese kutholakala ukuthi kunemiphumela emihle yokukhulisa i-nucleotide.Kodwa-ke, ukulimala okuhlukahlukene kwe-pathological kwatholakala kamuva ezithweni ezahlukene.6-9 Ubufakazi obengeziwe bukhombisa ukuthi izinguquko ze-pathophysiological ze-COVID-19 ziyinkimbinkimbi kakhulu.Ukuhlasela kwegciwane kubangela ukulimala kwezitho eziningi futhi amasosha omzimba asabela ngokweqile.Ukwanda kwe-serum kanye ne-alveolar cytokines kanye namaprotheni okuphendula ukuvuvukala kuye kwabonwa7, 10-12, kanye ne-lymphopenia kanye nama-T cell subsets angavamile atholakale ezigulini ezigula kakhulu.13, 14 Kubikwa ukuthi isilinganiso sama-neutrophils kuma-lymphocyte sesiphenduke inkomba ewusizo yokuhlukanisa ama-nodule e-thyroid ayingozi kanye ne-benign ekusebenzeni komtholampilo.I-15 NLR ingasiza futhi ukuhlukanisa iziguli ezine-ulcerative colitis nezilawuli ezinempilo.16 Iphinde ibambe iqhaza ku-thyroiditis futhi ihlotshaniswa nesifo sikashukela sohlobo 2.17, 18 RDW wuphawu lwe-erythrocytosis.Ucwaningo luye lwathola ukuthi kusiza ukuhlukanisa ama-nodules we-thyroid, ukuxilonga i-rheumatoid arthritis, isifo se-lumbar disc, kanye ne-thyroiditis.I-19-21 CRP iwukubikezela kwendawo yonke yokuvuvukala futhi ifundwe ezimweni eziningi.22 Kusanda kutholakala ukuthi i-NLR, i-RDW kanye ne-CRP nazo ziyabandakanyeka ku-COVID-19 futhi zidlala indima ebalulekile ekuxilongeni nasekuqaguleni kwalesi sifo.11, 14, 23-25 Ngakho-ke, imiphumela yokuhlolwa kwaselabhorethri ibalulekile ekuhloleni isimo sesiguli nokwenza izinqumo zokwelashwa.Sihlaziye kabusha imingcele yaselabhorethri yeziguli ezingama-52 ze-COVID-19 ezazilaliswe ezibhedlela eziqokiwe eSouth China ngokuya ngokwelashwa kwazo kwangaphambili nangemuva, ukuqina, neminyaka, ukuze siqhubeke siqonde izinguquko ze-pathological zesifo futhi sisize ukuphathwa komtholampilo esikhathini esizayo. we-COVID-19.
Lolu cwaningo lwenze ukuhlaziya okubukeziwe kweziguli ezingama-52 ze-COVID-19 ezingeniswe esibhedlela esiqokiwe iNanning Fourth Hospital kusukela ngoJanuwari 24, 2020 kuya kuMashi 2, 2020. Phakathi kwazo, ezingama-45 bezigula ngokulingene kanti ezi-5 bezigula kakhulu.Isibonelo, iminyaka yobudala isukela ezinyangeni ezi-3 kuye kwengama-85.Ngokobulili, kwakunabesilisa abangama-27 nabesifazane abangama-25.Isiguli siba nezimpawu ezifana nomkhuhlane, ukukhwehlela okomile, ukukhathala, ikhanda elibuhlungu, ukuphelelwa umoya, ukucinana kwamakhala, ikhala eligelezayo, umphimbo obuhlungu, ubuhlungu bemisipha, isifo sohudo kanye ne-myalgia.I-Computed tomography yabonisa ukuthi amaphaphu ayenamabala noma ingilazi ephansi, okubonisa inyumoniya.Thola ngokohlelo lwesi-7 lwe-Chinese COVID-19 Diagnosis and Treatment Guidelines.Kuqinisekiswe ukutholwa kwe-qPCR yesikhathi sangempela yama-nucleotide egciwane.Ngokwezinqubo zokuxilonga, iziguli zazihlukaniswe ngamaqembu aphakathi, anzima, futhi abucayi.Ezimweni ezilinganiselwe, isiguli siba nemfiva kanye nesifo sokuphefumula, futhi okutholwe ngezithombe kubonisa amaphethini e-pneumonia.Uma isiguli sihlangabezana nanoma iyiphi yalezi zindlela ezilandelayo, ukuxilongwa kunzima kakhulu: (a) ukucindezeleka kokuphefumula (izinga lokuphefumula ≥30 ukuphefumula / iminithi);(b) ukugcwala komoyampilo womunwe wokuphumula ≤93%;(c) umfutho we-arterial oxygen (PO2) )/Inspiratory fraction O2 (Fi O2) ≤300 mm Hg (1 mm Hg = 0.133 kPa).Uma isiguli sihlangabezana nanoma iyiphi yalezi zindlela ezilandelayo, ukuxilongwa kuba nzima: (a) ukwehluleka ukuphefumula okudinga ukushaywa umoya ngemishini;(b) ukwethuka;(c) okunye ukwehluleka kwezitho ezidinga ukwelashwa egunjini labagula kakhulu (ICU).Ngokwalezi zindlela ezingenhla, iziguli ezingu-52 kutholakale ukuthi zigula kakhulu ezimweni ezi-2, ezigula kakhulu ezimweni ezi-5, futhi ukugula okulinganiselwe kwezingu-45.
Zonke iziguli, kuhlanganise neziguli ezilinganiselayo, ezinzima nezigula kakhulu, zelashwa ngokuhambisana nalezi zinqubo eziyisisekelo ezilandelayo: (a) Ukwelashwa okujwayelekile kwe-adjuvant;(b) Ukwelashwa ngezidambisigciwane: i-lopinavir/ritonavir kanye ne-α-interferon;(c) Umthamo wefomula yomuthi wesintu waseShayina ungalungiswa kuye ngesimo sesiguli.
Lolu cwaningo lugunyazwe yiKomidi Lokubuyekeza le-Research Institute of Nanning Fourth Hospital futhi lwasetshenziselwa ukuqoqa ulwazi lwesiguli.
Ukuhlaziywa kwe-hematology yegazi ye-peripheral: ukuhlaziywa kwe-hematology okujwayelekile kwegazi le-peripheral kwenziwa ku-Mindray BC-6900 hematology analyzer (Mindray) kanye ne-Sysmex XN 9000 hematology analyzer (Sysmex).Isampula yegazi le-fasting ethylenediaminetetraacetic acid (EDTA) ye-anticoagulant yaqoqwa ekuseni ngemva kokuba isiguli singeniswe esibhedlela.Ukuhlolwa kokuvumelana phakathi kwabahlaziyi begazi ababili abangenhla kwaqinisekiswa ngokuvumelana nezinqubo zokulawula ikhwalithi yaselabhorethri.Ekuhlaziyweni kwe-hematology, ukubala nokuhlukaniswa kwamaseli amhlophe egazi (WBC), amangqamuzana egazi abomvu (RBC) kanye nenkomba kutholakala kanye nama-scatter plots nama-histograms.
I-Flow cytometry ye-T lymphocyte subpopulations: BD (Becton, Dickinson and Company) I-FACSCalibur flow cytometer yasetshenziselwa ukuhlaziywa kwe-cytometry yokugeleza ukuze kuhlaziywe ukutholakala kwe-T cell.Hlaziya idatha nge-software ye-MultiSET.Ukulinganisa kwenziwa ngokuhambisana nezinqubo ezijwayelekile zokusebenza kanye nemiyalelo yomkhiqizi.Sebenzisa ishubhu leqoqo legazi le-EDTA elinqanyuliwe ukuze uqoqe u-2 ml wegazi le-venous.Hlanganisa ngobumnene isampula ngokuphendula ishubhu yesampula izikhathi ezimbalwa ukuze uvimbele ukufingqa.Ngemva kokuba isampula seliqoqwe, lithunyelwa elabhorethri futhi lihlaziywe phakathi namahora angu-6 ekamelweni lokushisa.
Ukuhlaziywa kwe-Immunofluorescence: Amaprotheni e-C-reactive (CRP) kanye ne-procalcitonin (PCT) ahlaziywa ngokushesha ngemva kokuphothulwa kokuhlaziywa kusetshenziswa amasampula egazi ahlaziywa nge-hematology, futhi ahlaziywa ku-FS-112 immunofluorescence analyzer (Wondfo Biotech Co., LTD.) ukuhlaziya.) Landela imiyalelo yomkhiqizi kanye namazinga enqubo yaselabhorethri.
Hlaziya i-serum alanine aminotransferase (ALT) kanye ne-aspartate aminotransferase (AST) ku-HITACHI LABOSPECT008AS chemical analyzer (HITACHI).Isikhathi se-prothrombin (PT) sahlaziywa ku-STAGO STA-R Evolution analyzer (Diagnostica Stago).
Reverse transcription quantitative polymerase chain reaction (RT-qPCR): Sebenzisa izifanekiso ze-RNA ezihlukanisiwe kuma-nasopharyngeal swabs noma ukukhishwa kwepheshana lokuphefumula eliphansi ukuze wenze i-RT-qPCR ukuze uthole i-SARS-CoV-2.Ama-Nucleic acid ahlukaniswa ku-SSNP-2000A nucleic acid yesikhulumi sokuhlukanisa okuzenzakalelayo (Bioperfectus Technologies).Ikhithi yokuthola inikezwe i-Sun Yat-sen University Daan Gene Co., Ltd. kanye ne-Shanghai BioGerm Medical Biotechnology Co., Ltd. Umjikelezo oshisayo wenziwa nge-ABI 7500 thermal cycler (Applied Biosystems).Imiphumela yokuhlolwa kwe-viral nucleoside ichazwa njengephozithivu noma inegethivu.
Isofthiwe ye-SPSS version 18.0 yasetshenziselwa ukuhlaziya idatha;Ukuhlolwa kwesampula okubhanqiwe, ukuhlolwa kwe-t-sampula okuzimele, noma ukuhlolwa kwe-Mann-Whitney U kusetshenzisiwe, futhi inani elingu-P <.05 libhekwe njengelibalulekile.
Iziguli ezinhlanu ezigula kakhulu kanye neziguli ezimbili ezigula kakhulu zazindala kuneqembu elilinganiselwe (69.3 vs. 40.4).Ulwazi oluningiliziwe lweziguli ezi-5 ezigula kakhulu kanye nezi-2 ezigula kakhulu ziboniswa kuThebula 1A no-B. Iziguli ezinzima nezigula kakhulu ngokuvamile ziphansi kuma-T cell subsets kanye nokubala okuphelele kwe-lymphocyte, kodwa isibalo samangqamuzana amhlophe egazi cishe sijwayelekile, ngaphandle kweziguli. namaseli amhlophe egazi aphakeme (11.5 × 109/L).Ama-neutrophils nama-monocyte nawo ngokuvamile aphakeme.I-serum PCT, ALT, AST kanye ne-PT amanani eziguli ezi-2 ezigula kakhulu kanye nesiguli esisodwa esigula kakhulu ayephezulu, kanti i-PT, ALT, AST yesiguli esisodwa esigula kakhulu kanye neziguli ezi-2 ezigula kakhulu zazihlotshaniswa kahle.Cishe zonke iziguli eziyi-7 zazinamazinga aphezulu e-CRP.Ama-Eosinophils (EOS) nama-basophils (BASO) avame ukubaphansi ezigulini ezigula kakhulu nezigula kakhulu (Ithebula 1A no-B).Ithebula 1 libala incazelo yobubanzi obujwayelekile bemingcele ye-hematological kubantu abadala baseShayina.
Ukuhlaziywa kwezibalo kubonise ukuthi ngaphambi kokwelashwa, ama-CD3+, CD4+, CD8+ T cell, ama-lymphocyte aphelele, ububanzi bokusabalalisa kwe-RBC (RDW), ama-eosinophil nama-basophil ayephansi kakhulu kunangemva kokwelashwa (P = .000,. 000, .000, .012, . 04, .000 kanye .001).Izinkomba zokuvuvukala kwama-neutrophils, i-neutrophil/lymphocyte ratio (NLR) kanye ne-CRP ngaphambi kokwelashwa zaziphakeme kakhulu kunangemva kokwelashwa (P = .004, .011 kanye .017, ngokulandelana).I-Hb ne-RBC yehle kakhulu ngemva kokwelashwa (P = .032, .026).I-PLT yanda ngemva kokwelashwa, kodwa yayingabalulekile (P = .183) (Ithebula 2).
Ama-T cell subsets (CD3+, CD4+, CD8+), ama-lymphocyte aphelele nama-basophil eziguli ezinzima nezigula kakhulu ayephansi kakhulu kuneziguli ezilinganiselwe (P = .025, 0.048, 0.027, 0.006 kanye .046).Amazinga we-neutrophils, i-NLR, i-PCT ne-CRP ezigulini ezinzima nezigula kakhulu ayephakeme kakhulu kuneziguli ezilinganiselwe (P = .005, .002, .049 kanye .002, ngokulandelana).Iziguli ezinzima nezigula kakhulu zine-PLT ephansi kuneziguli ezilinganiselayo;nokho, umehluko wawungabalulekile ngokwezibalo (Ithebula 3).
Ama-CD3+, CD8+, ama-lymphocyte esewonke, ama-platelet, nama-basophil eziguli ezineminyaka engaphezu kwengu-50 ubudala ayephansi kakhulu kunalawo eziguli ezingaphansi kweminyaka engu-50 ubudala (P = .049, 0.018, 0.019, 0.010 kanye .039, ngokulandelana), kuyilapho labo abangaphezu kweminyaka engu-50 ubudala. Ama-neutrophils eziguli ezineminyaka engu-50, isilinganiso se-NLR, amazinga e-CRP kanye ne-RDW ayephakeme kakhulu kunalawo eziguli ezingaphansi kweminyaka engu-50 ubudala (P = .0191, 0.015, 0.009, kanye .010, ngokulandelana) (Ithebula 4).
I-COVID-19 ibangelwa ukutheleleka nge-coronavirus i-SARS-CoV-2, eyaqala ukuvela e-Wuhan, e-China ngo-December 2019. Ukuqubuka kwe-SARS-CoV-2 kwasabalala ngokushesha ngemva kwalokho futhi kwaholela kubhubhane lomhlaba wonke.1-3 Ngenxa yolwazi olulinganiselwe lwe-epidemiology kanye ne-pathology yegciwane, izinga lokufa ekuqaleni kokugqashuka liphezulu.Yize ingekho imishanguzo elwa namagciwane, ukuphathwa kokulandelela kanye nokwelashwa kwe-COVID-19 kuye kwathuthukiswa kakhulu.Lokhu kuyiqiniso ikakhulukazi e-China lapho i-adjuvant therapy ihlanganiswa nemithi yendabuko yamaShayina ukuze kwelashwe amacala angaphambi kwesikhathi naphakathi.Iziguli ezingama-26 ze-COVID-19 zizuze ekuqondeni kangcono izinguquko ze-pathological kanye nemingcele yaselabhorethri yalesi sifo.isifo.Kusukela lapho, izinga lokufa liye lehla.Kulo mbiko, abekho abantu abashonile phakathi kwamacala angama-52 ahlaziywe, okuhlanganisa neziguli eziyisi-7 ezigula kakhulu nezigula kakhulu (Ithebula 1A kanye no-B).
Ukubhekwa kwemitholampilo kuthole ukuthi iningi leziguli ezine-COVID-19 linciphise ama-lymphocyte kanye nama-T cell subpopulations, ahlobene nobunzima besifo.13, 27 Kulo mbiko, kutholakale ukuthi ama-CD3+, CD4+, CD8+ T cell, i-lymphocyte ephelele, i-RDW ngaphambi kokwelashwa, ama-eosinophil nama-basophil ayephansi kakhulu kunangemva kokwelashwa (P = .000, .000, .000, .012, .04, .000 kanye .001).Imiphumela yethu iyafana nemibiko yangaphambilini.Le mibiko inokubaluleka komtholampilo ekuqapheni ubukhali be-COVID-19.8, 13, 23-25, 27, kuyilapho izinkomba zokuvuvukala kwama-neutrophils, neutrophils/lymphocyte ratio (NLR ) Kanye ne-CRP ngemva kokwelashwa kwangaphambili kunokwelashwa (P = .004, . 011 kanye no-.017, ngokulandelana), eziye zaqashelwa futhi zabikwa ngaphambilini ezigulini ze-COVID-19.Ngakho-ke, le mingcele ithathwa njengezinkomba eziwusizo ekwelapheni i-COVID-19.8.Ngemva kokwelashwa, i-hemoglobin ye-11 namangqamuzana egazi abomvu ancishiswa kakhulu (P = .032, 0.026), okubonisa ukuthi isiguli sine-anemia ngesikhathi sokwelashwa.Ukwanda kwe-PLT kwabonwa ngemva kokwelashwa, kodwa kwakungabalulekile (P = .183) (Ithebula 2).Ukuncipha kwama-lymphocyte kanye ne-T cell subpopulations kucatshangwa ukuthi kuhlobene nokuncipha kwamaseli kanye ne-apoptosis lapho enqwabelana ezindaweni ezivuvukalayo ezilwa naleli gciwane.Noma, kungenzeka ukuthi zidliwe ukugcinwa ngokweqile kwama-cytokines namaprotheni avuthayo.8, 14, 27-30 Uma i-lymphocyte kanye ne-T cell subsets ilokhu iphansi futhi isilinganiso se-CD4+/CD8+ siphezulu, ukubikezelwa kubi.29 Ekuqapheleni kwethu, ama-lymphocyte kanye nama-T cell subsets alulame ngemva kokwelashwa, futhi wonke amacala angu-52 eselashwa (Ithebula 1).Amazinga aphezulu we-neutrophils, i-NLR, ne-CRP abonwa ngaphambi kokwelashwa, bese ehla kakhulu ngemva kokwelashwa (P = .004, .011, kanye .017, ngokulandelana) (Ithebula 2).Umsebenzi we-T cell subsets ekuthelelekeni nasekuphenduleni kwamasosha omzimba kuye kwabikwa ngaphambilini.29, 31-34
Njengoba inani leziguli ezinzima nezigula kakhulu lincane kakhulu, asizange senze ukuhlaziywa kwezibalo kumapharamitha phakathi kweziguli ezinzima nezigula kakhulu kanye neziguli ezilinganiselwe.Ama-T cell subsets (CD3+, CD4+, CD8+) kanye nama-lymphocyte esewonke eziguli ezinzima nezigula kakhulu aphansi kakhulu kunalawo eziguli ezilinganiselayo.Amazinga we-neutrophils, i-NLR, i-PCT, ne-CRP ezigulini ezinzima nezigula kakhulu zaziphakeme kakhulu kuneziguli ezilinganiselwe (P = .005, .002, .049, kanye .002, ngokulandelana) (Ithebula 3).Izinguquko kumapharamitha aselabhorethri zihlobene nobunzima be-COVID-19.35.36 Imbangela ye-basophilia ayicacile;lokhu kungase kube ngenxa yokusetshenziswa kokudla ngenkathi kulwa negciwane endaweni yokutheleleka okufana nama-lymphocyte.35 Ucwaningo lwathola ukuthi iziguli ezine-COVID-19 enzima nazo zazinciphise ama-eosinophil;I-14 Nokho, idatha yethu ayizange ibonise ukuthi lesi simo singase sibe ngenxa yenani elincane lamacala anzima futhi abucayi abonwa ocwaningweni.
Kuyathakazelisa ukuthi sithole ukuthi ezigulini ezinzima nezigula kakhulu, kukhona ukuhlobana okuhle phakathi kwamanani e-PT, ALT, kanye ne-AST, okubonisa ukuthi ukulimala kwezitho eziningi kwenzeka ekuhlaselweni kwegciwane, njengoba kushiwo kokunye ukubonwa.37 Ngakho-ke, angase abe amapharamitha amasha awusizo wokuhlola impendulo kanye nesibikezelo sokwelashwa kwe-COVID-19.
Ukuhlaziywa okwengeziwe kubonise ukuthi i-CD3+, CD8+, i-lymphocyte isiyonke, amaplatelet kanye nama-basophil eziguli ezingaphezu kweminyaka engu-50 ubudala ayephansi kakhulu kunalawo eziguli ezingaphansi kweminyaka engu-50 ubudala (P = P = .049, .018, .019, .010 kanye. 039, ngokulandelana), kuyilapho amazinga ama-neutrophils, i-NLR, i-CRP, ne-RBC RDW ezigulini ezingaphezu kweminyaka engu-50 ubudala ayephakeme kakhulu kunalawo eziguli ezingaphansi kweminyaka engu-50 ubudala (P = .0191, 0.015, 0.009, kanye .010 , ngokulandelana) (Ithebula 4).Le miphumela iyafana nemibiko yangaphambilini.14, 28, 29, 38-41 Ukuncipha kwe-T cell subpopulations kanye nezilinganiso eziphezulu ze-CD4+/CD8+ T cell kuhlobene nobunzima besifo;amacala asebekhulile avame ukuba nzima kakhulu;Ngakho-ke, ama-lymphocyte amaningi azodliwa ekuphenduleni kwamasosha omzimba noma alimele Kakhulu.Ngokufanayo, i-RBC RDW ephakeme ikhombisa ukuthi lezi ziguli zine-anemia.
Imiphumela yethu yocwaningo iphinde iqinisekise ukuthi amapharamitha e-hematological abaluleke kakhulu ekuqondeni kangcono izinguquko ze-clinicopathological yeziguli ze-COVID-19 kanye nokwenza ngcono ukuqondiswa kokwelashwa kanye nokubikezela.
U-Liang Juanying kanye noNong Shaoyun baqoqa idatha nolwazi lomtholampilo;U-Jiang Liejun no-Chi Xiaowei benze ukuhlaziya idatha;U-Dewu Bi, uJun Cao, uLida Mo, no-Xiaolu Luo benze ukuhlaziya okujwayelekile;U-Huang Huayi nguyena owayephethe ukukhulelwa nokubhala.
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Isikhathi sokuthumela: Jul-22-2021