Sisebenzisa amakhukhi ukuthuthukisa ulwazi lwakho.Ngokuqhubeka nokuphequlula le webhusayithi, uyavumelana nokusebenzisa kwethu amakhukhi.Ulwazi olwengeziwe.
Umphumela wokuhlolwa oqondile uncike ekuthembekeni kwephepha lokuhlola umchamo.Kungakhathaliseki ukuthi yiluphi uhlobo lomkhiqizo, ukuphathwa okungalungile kwemichilo kungaholela emiphumeleni eyiphutha, okungaholela ekuxilongweni okungalungile okungenzeka.Ibhodlela lekhasi eliqiniswe ngokungafanele noma elifakwe kabusha lidalula okuqukethwe endaweni enomswakama emoyeni wasendlini, okungase kuthinte ubuqotho bekhasi, kubangele ukuwohloka kwe-reagent, futhi ekugcineni kuholele emiphumeleni eyiphutha.
U-Crolla et al.1 wenze ucwaningo lapho imichilo yokuhlola yavezwa emoyeni wasendlini, futhi amathuluzi nama-reagent strips abakhiqizi abathathu kwaqhathaniswa.Isiqukathi se-strip kufanele sivalwe ngokuvumelana nezincomo zomkhiqizi ngemuva kokusetshenziswa, ngaphandle kwalokho kuzodala ukuchayeka komoya wasendlini.Lesi sihloko sibika imiphumela yocwaningo, siqhathanisa umugqa wokuhlola umchamo we-MULTISTIX® 10SG kanye nesihlaziyi se-Siemens CLINTEK Status®+ nemikhiqizo evela kwabanye abakhiqizi ababili.
Imichilo ye-Siemens MULTISTIX® yochungechunge lwe-urine (Umfanekiso 1) inebhendi entsha yokuhlonza (ID).Uma kuhlanganiswe ne-CLINITEK Status range⒜ isihlaziyi sekhemistri yomchamo eboniswe emfanekisweni, uchungechunge lokuhlola ikhwalithi okuzenzakalelayo (Ukuhlola Okuzenzakalelayo) 2.
Umfanekiso 2. Abahlaziyi bochungechunge lwesimo se-CLINITEK basebenzisa i-algorithm ukuze bathole imichilo ye-reagent eyonakele umswakama ukuze basize ukuqinisekisa imiphumela yekhwalithi.
U-Kroll et al.Ucwaningo luhlole imiphumela ekhiqizwe yinhlanganisela yemigqa yokuhlola nabahlaziyi abavela kubakhiqizi abathathu:
Ngomkhiqizi ngamunye, amasethi amabili e-reagent strips alungiswa.Iqembu lokuqala lamabhodlela lavulwa lavezwa emoyeni wangaphakathi (22oC kuya ku-26oC) kanye nomswakama wangaphakathi (26% kuya ku-56%) izinsuku ezingaphezu kwezingama-40.Lokhu kwenzelwa ukulingisa ukuchayeka okungavezwa umugqa we-reagent lapho u-opharetha engasivali kahle isiqukathi se-reagent strip (umugqa wokucindezela).Eqenjini lesibili, ibhodlela laligcinwa livaliwe kuze kube yilapho isampula yomchamo ihlolwa (ayikho ibha yokucindezela).
Cishe amasampula omchamo wesiguli angama-200 ahlolwa kuzo zontathu inhlanganisela yomkhiqizo.Amaphutha noma ivolumu enganele phakathi nokuhlolwa kuzodala isampula ukuthi ihluke kancane.Isamba senani lamasampula ahlolwe umkhiqizi linemininingwane kuThebula 1. Ukuhlolwa kwe-reagent strip kwenziwa kubahlaziyi abanikeziwe abalandelayo kusetshenziswa amasampuli esiguli:
Ukuhlolwa kwesampula yomchamo kuqedwa phakathi nezinyanga ezintathu.Kusethi ngayinye yemicu, egcizelelwe futhi engacindezelwanga, amasampula okuhlola ayaphindwa kuwo wonke amasistimu wezinsimbi.Ngenhlanganisela ngayinye yomugqa ne-analyzer, sebenzisa lawa masampuli ayimpinda ngokuqhubekayo.
Isikhungo sokwelapha iziguli ezingalalisiwe esisendaweni yasemadolobheni yindawo yocwaningo.Ukuhlolwa okuningi kwenziwa abasizi bezokwelapha nabasebenzi abahlengikazi, futhi ukuhlolwa kwezikhawuko kwenziwa izisebenzi zaselabhorethri eziqeqeshiwe (ASCP).
Le nhlanganisela yama-opharetha iphindaphinda izimo zokuhlola ezinembile esikhungweni sokwelashwa.Ngaphambi kokuqoqa idatha, bonke opharetha baqeqeshwa futhi amakhono abo ahlolwa kubo bobathathu abahlaziyi.
Ocwaningweni olwenziwa nguCrolla et al., ukuvumelana kokusebenza kohlaziyo phakathi kwemichilo ye-reagent engacindezelwanga negcizelelwe kwahlolwa ngokubheka ukuphindwa kokuqala kwesethi ngayinye yokuhlola, kwase kuthi ukuvumelana kwaqhathaniswa nokungagcizelelwe (ukulawula) Qhathanisa ukuvumelana. phakathi kwemiphumela etholiwe)-Kopisha 1 futhi Kopisha 2.
Umugqa wokuhlola we-MULTISTIX 10 SG ofundwe yi-CLINITEK Status+ Analyzer yakhelwe ukubuyisela ifulegi lephutha esikhundleni somphumela wangempela ngokushesha nje lapho isistimu ithola ukuthi umugqa wokuhlola uthinteke kakhulu ngenxa yokuchayeka ngokweqile kumswakama wendawo.
Lapho kuhlolwa ku-CLINITEK Status+ Analyzer, ngaphezu kuka-95% (95% isikhathi sokuzethemba: 95.9% kuya ku-99.7%) emicu yokuhlola ye-MULTISTIX 10 SG egcizelelwe ibuyisela ifulegi lephutha, okubonisa ngokunembile ukuthi imicu yokuhlola ithintekile futhi ngenxa yalokho ayithinteki. ilungele ukusetshenziswa (Ithebula 1) .
Ithebula 1. Iphutha lokumaka imiphumela yemigqa yokuhlola engacindezelwanga futhi ecindezelwe (umswakama owonakele), ehlukaniswa ngumkhiqizi.
Isivumelwano sephesenti phakathi kwezimpinda ezimbili zemichilo ye-reagent engenakucindezeleka kuzo zonke izinto zabakhiqizi abathathu (okunembayo kanye nesethi engu-±1) ukusebenza kwemichilo engenakucindezeleka (izimo zokulawula).Ababhali basebenzise isikali esingu-±1 ngoba lokhu ukuhluka okujwayelekile okwamukelekayo kwephepha lokuhlola umchamo.
Ithebula 2 kanye neThebula 3 likhombisa imiphumela efingqiwe.Ngokusebenzisa ukunemba noma isikali esingu-±1, awukho umehluko obalulekile ekuphindaphindeni okufanayo phakathi kwemichilo emithathu yabakhiqizi ngaphansi kwezimo ezingenakucindezeleka (p>0.05).
Ngokwesilinganiso sokuphindaphinda esingaguquguquki semichilo engenaso ingcindezi yabanye abakhiqizi, kwaphawulwa ukuthi ekuphindaphindweni okubili kwemichilo ye-reagent engenaso ukucindezeleka, kunezibonelo ezimbili kuphela ezihlukene zokungaguquguquki kwephesenti.Lezi zibonelo zigqanyisiwe.
Kumaqembu e-Roche namaqembu okuhlola ukuxilonga, nquma isivumelwano sephesenti phakathi kokuphindaphinda kokuqala kwebha egcizelelwe kanye nokuphinda kokuqala kwebha engacindezelwe ukuze kuhlolwe ukusebenza komugqa wokuhlola ukucindezeleka kwendawo.
Amathebula 4 no-5 afingqa imiphumela yomhlaziyi ngamunye.Iphesenti lesivumelwano lalaba bahlaziyi ngaphansi kwezimo zokucindezeleka lihluke kakhulu kumaphesenti esivumelwano sezimo zokulawula, futhi limakwe ngokuthi “libalulekile” kulawa mathebula (p<0.05).
Njengoba izivivinyo ze-nitrate zibuyisela imiphumela kanambambili (emibi/emihle), zibhekwa njengamakhandidethi ukuze zihlaziywe kusetshenziswa isethi yemibandela engu-±1.Ngokuphathelene ne-nitrate, uma kuqhathaniswa nokuvumelana kwe-96.5% kuya ku-98%, imichilo yokuhlola ukucindezeleka ye-Diagnostic Test Group kanye ne-Roche ine-11.3% kuphela kuya ku-14.1 phakathi kwemiphumela ye-nitrate etholwe ukuphindaphinda 1 ngaphansi kwezimo ezingenakucindezeleka nokuphindaphinda 1 ngaphansi kwezimo zokucindezeleka.Isivumelwano se-% sibonwe phakathi kokuphindaphinda kwesimo esingacindezelwe (ukulawula).
Ukuze uthole izimpendulo ze-analyte zedijithali noma okungezona kanambambili, ukuhlolwa kwe-ketone, i-glucose, i-urobilinogen, namangqamuzana egazi amhlophe okwenziwa ku-Roche nemicu yokuhlola yokuxilonga kwakunephesenti eliphakeme kakhulu lomehluko ekuphumeni kwebhulokhi enembile phakathi kwengcindezi nemicu yokuhlola engacindezelwanga. .
Lapho izinga lokungaguquguquki linwetshelwa eqenjini elingu-±1, ngaphezu kwamaprotheni (ukungaguquguquki okungu-91.5%) namangqamuzana egazi amhlophe (ukungaguquguquki kuka-79.2%), ukwehlukana kwemicu yokuhlola ye-Roche kwancishiswa kakhulu, futhi amazinga amabili angaguquguquki futhi akukho ngcindezi (Ukuqhathanisa ) Kunezivumelwano ezihluke kakhulu.
Endabeni yama-test strips eqenjini lokuhlola ukuxilonga, ukuhambisana kwephesenti le-urobilinogen (11.3%), amangqamuzana egazi amhlophe (27.7%), kanye ne-glucose (57.5%) kuqhubekile nokuncipha kakhulu uma kuqhathaniswa nezimo zabo zokungacindezeleki.
Ngokusekelwe kudatha etholwe ngomugqa we-reagent ye-Roche kanye ne-Diagnostic Test Group kanye nenhlanganisela yokuhlaziya, umehluko omkhulu phakathi kwemiphumela engacindezelwanga necindezelwe wabonwa ngenxa yokuchayeka kumswakama nomoya wegumbi.Ngakho-ke, ngokusekelwe emiphumeleni eyiphutha evela emicu eveziwe, ukuxilongwa okungalungile nokwelashwa kungase kwenzeke.
Umshini wokuxwayisa ozenzakalelayo ku-Siemens analyzer ivimbela imiphumela ukuthi ingabikwa lapho kutholwa ukuchayeka komswakamo.Ocwaningweni olulawulwayo, umhlaziyi angavimbela imibiko engamanga futhi akhiqize imilayezo yamaphutha esikhundleni sokukhiqiza imiphumela.
I-CLINITEK Status+ analyzer kanye ne-Siemens MULTISTIX 10 SG yemigqa yokuhlola umchamo ehlanganiswe nobuchwepheshe bokuhlola okuzenzakalelayo ingathola ngokuzenzakalelayo imicu yokuhlola engase ithikamezeke ukuswakama okweqile.
I-CLINITEK Status+ Analyzer ayitholi nje kuphela imicu yokuhlola ye-MULTISTIX 10 SG ethintwa umswakamo oweqile, kodwa futhi ivimbela ukubikwa kwemiphumela okungenzeka ayinembile.
Abahlaziyi be-Roche kanye ne-Diagnostic Test Group abanalo isistimu yokuthola umswakama.Nakuba umugqa wokuhlola uthintwa ukuswakama ngokweqile, lawa mathuluzi amabili abika imiphumela yesampula yesiguli.Imiphumela ebikiwe ingase ingalungile, ngoba ngisho nesampula yesiguli esifanayo, imiphumela ye-analyte izohluka phakathi kwemigqa yokuhlola engaveziwe (engagcizeleleki) kanye neveziwe (ecindezelwe).
Ekuhloleni okuhlukahlukene kwendawo yaselabhorethri, u-Crolla nethimba lakhe baqaphela ukuthi isikhathi esiningi ikepisi lebhodlela le-urine strip lalikhishwa kancane noma likhishwe ngokuphelele.Ukuhlaziywa kugcizelela isidingo sezinkampani zokuhlola ukuze izincomo zomenzi ngamunye zisetshenziswe ngokuqinile ukugcina isiqukathi setheyiphu simboziwe lapho itheyiphu ingakhishwa ukuze kuqhutshekwe nokuhlaziywa.
Ezimeni lapho kunama-opharetha amaningi (okwenza ukusungula ukuthobela kube nzima kakhulu), kuyasiza futhi ukusebenzisa isistimu ukwazisa umhloli ngomugqa othintekile ukuze ukuhlola kungenziwa.
Kwenziwe ngezinto ezisetshenziswa ekuqaleni ezidalwe ngu-Lawrence Crolla, uCindy Jiménez, no-Pallavi Patel baseNorthwest Community Hospital e-Arlington Heights, Illinois.
Isixazululo se-point-of-care siklanyelwe ukuhlinzeka ngezivivinyo zokuxilonga ezisheshayo, ezilula futhi ezisebenziseka kalula.Kusukela ekamelweni lezimo eziphuthumayo kuya ehhovisi likadokotela, izinqumo zokuphathwa komtholampilo zingenziwa ngokushesha, ngaleyo ndlela kuthuthukiswe ukuphepha kwesiguli, imiphumela yomtholampilo, nokwaneliseka kwesiguli sonke.
Inqubomgomo yokuqukethwe okuxhasiwe: Ama-athikili nokuqukethwe okuhlobene okushicilelwe i-News-Medical.net kungase kuvele emithonjeni yobudlelwano bethu bebhizinisi obukhona, inqobo nje uma okuqukethwe okunjalo kunezela ukubaluleka kumongo oyinhloko wokuhlela we-News-Medical.Net, okungukuthi, imfundo nokwazisa iwebhusayithi Izivakashi ezinentshisekelo ocwaningweni lwezokwelapha, isayensi, izisetshenziswa zezokwelapha kanye nokwelashwa.
Ukuxilongwa kwe-Siemens Healthineers Point of Care.(2020, Mashi 13).Ucwaningo oluqhathanisayo lwezihlaziyi zomchamo ezintathu, ezisetshenziselwa ukuhlola ukuhlolwa kokuswakama okuzenzakalelayo kwemicu yokuhlaziya umchamo efundwa ithuluzi.Izindaba-Zokwelashwa.Ibuyiswe ngoJulayi 13, 2021 kusukela ku-https://www.news-medical.net/whitepaper/20180123/A-Comparative-Study-of-Three-Urinalysis-Analyzers-for-Evaluation-of-Automated-Humidity-Check- -Instrument-Read-Urinalysis-Strips.aspx.
Ukuxilongwa kwe-Siemens Healthineers Point of Care."Ucwaningo oluqhathaniswayo lwezihlaziyi zomchamo ezintathu ezisetshenziselwa ukuhlola ukuhlolwa kokuswakama okuzenzakalelayo komugqa wokuhlaziya umchamo ngokufunda kwethuluzi".Izindaba-Zokwelashwa.Julayi 13, 2021. .
Ukuxilongwa kwe-Siemens Healthineers Point of Care."Ucwaningo oluqhathaniswayo lwezihlaziyi zomchamo ezintathu ezisetshenziselwa ukuhlola ukuhlolwa kokuswakama okuzenzakalelayo komugqa wokuhlaziya umchamo ngokufunda kwethuluzi".Izindaba-Zokwelashwa.https://www.news-medical.net/whitepaper/20180123/A-Comparative-Study-of-Three-Urinalysis-Analyzers-for-Evaluation-of-Automated-Humidity-Check-for-Instrument-Read-Urinalysis- Strip .aspx.(Ifinyelelwe ngoJulayi 13, 2021).
Ukuxilongwa kwe-Siemens Healthineers Point of Care.2020. Ucwaningo oluqhathanisayo lwabahlaziyi bomchamo abathathu olusetshenziselwa ukuhlola ukuhlolwa kokuswakama okuzenzakalelayo komugqa wokuhlaziya umchamo ngokufundwa kwethuluzi.I-News-Medical, ibukwe ngoJulayi 13, 2021, https://www.news-medical.net/whitepaper/20180123/A-Comparative-Study-of-Three-Urinalysis-Analyzers-for-Evaluation-of-Automated- Humidity- Hlola -for-Instrument-Read-Urinalysis-Strips.aspx.
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Isikhathi sokuthumela: Jul-14-2021